Development of Sustainable Photo-protectants for UV-Sensitive Drugs

Summary

Overview

Existing strategies for photo-protection of drugs include use of mineral-based excipients and/or polymer coatings. However, with the drive towards a more sustainable pharmaceutical industry, greener alternatives are being explored. One such alternative could be the use of the secondary metabolite scytonemin, an indole-derived compound produced by a range of cyanobacteria, including Nostoc commune. We have recently evaluated the physicochemical properties of scytonemin and established the process through which it could offer photo-protection.

We propose that scytonemin is a viable photo-protectant for solid dosage forms, including the marinomycins and other established drugs such as omeprazole, chlorpromazine and chlorodiazepoxide. This project will seek to develop a sustainable extraction strategy for scytonemin and explore its potential as a photo-protective coating for compressed tablets.

Underlying Aim

To develop a novel ultraviolet filter for solid dosage forms using the principles of green chemistry.

Specific Objectives/Methodology

1. Optimisation of growth conditions for Nostoc commune to enable maximum scytonemin production.
2. Development of a green extraction methodology for scyntonemin using in silico modelling and a surface response methodology.
3. Incorporation of scyntonemin into solid dosage forms containing UV-sensitive APIs and evaluation of the formulation, including stability/shelf-life.

Impact

Reduction in pharmaceutical waste due to instability/short shelf-and the associated pharmacoeconomic burden.

Essential criteria

Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study.

We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction.

In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications.

• Experience using research methods or other approaches relevant to the subject domain
• Sound understanding of subject area as evidenced by a comprehensive research proposal
• A comprehensive and articulate personal statement
• Clearly defined research proposal detailing background, research questions, aims and methodology
• Research proposal of 1500 words detailing aims, objectives, milestones and methodology of the project

Desirable Criteria

If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.

• Experience using research methods or other approaches relevant to the subject domain
• Work experience relevant to the proposed project
• Experience of presentation of research findings

Equal Opportunities

The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities.

Appointment will be made on merit.

Funding and eligibility