Long-term Statin Use, Global Lipid Homeostasis & the Gut-Brain Axis

Summary

Overview

Statins are the most widely prescribed drug for primary and secondary prevention of  atherosclerotic cardiovascular disease (ASCVD). Historically, these hypolipidaemic agents were mainly used in older patient groups, but more recent evidence supports their use in younger, high risk individuals. This highlights the need to better understand the long-term impact of statins beyond the LDL-cholesterol lowering paradigm.

One approach is to explore global lipid homeostasis in individuals who have been receiving long-term statin therapy. Global lipid homeostasis refers to the overall balance of lipids in vivo and involves a series of enzyme-mediated reactions that can have a significant impact on the risk of developing ASCVD. Of particular interest is how long-term statin use affects the metabolism of docosahexaenoic acid, an omega-3 fatty acid that is a major structural component of the brain. Likewise, the impact of statin use on adipokines and the gut-brain axis is of relevance when we consider the the future elderly population who have had long-term statin therapy.

Underlying Aim

To explore global lipid homeostasis in individuals receiving long-term statin monotherapy with particular emphasis on fatty acids associated with the gut-brain axis.

Specific Objectives/Methodology

1. Case control study design, recruitment of volunteers, sample collection and storage in line with current legislation.
2. Measurement of a range of metrics of lipid homeostasis including serum phospholipid transfer protein specific activity by fluorometric assay and  docosahexaenoic acid by MALDI-MS/MS.
3. Statistical analysis including dimensionality reduction and multivariate analysis of covariance.

Impact

Contribution to evidence-based practice with respect to long-term statin use and the impact on lipid metabolism/gut-brain interactions.

Applications for this project are restricted to those who have had full registration with the General Medical Council for a minimum of three years (see here).

Applications for both full-time and part-time (or a mixture of both) are welcome.

This project has bench fees of £2000 to cover use of mass spectrometry core facilities.

AccessNI clearance required

Please note, the successful candidate will be required to obtain AccessNI clearance prior to registration due to the nature of the project.

Essential criteria

Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study.

We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction.

In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications.

• Experience using research methods or other approaches relevant to the subject domain
• Sound understanding of subject area as evidenced by a comprehensive research proposal
• A comprehensive and articulate personal statement
• Clearly defined research proposal detailing background, research questions, aims and methodology
• Research proposal of 1500 words detailing aims, objectives, milestones and methodology of the project

Desirable Criteria

If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.

• Experience using research methods or other approaches relevant to the subject domain
• Work experience relevant to the proposed project
• Experience of presentation of research findings

Equal Opportunities

The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities.

Appointment will be made on merit.

Funding and eligibility