Unlocking the Brain's Balance: Understanding Astrocyte Influence on Neural Communication Through Computer Modelling

Summary

This cutting-edge research project at Ulster University dives into one of the brain's most fascinating mechanisms: the conversation between brain cells that keeps our minds healthy and functioning.
Our brains are incredibly complex networks where different types of cells work together in perfect harmony. At the centre of this research are astrocytes - star-shaped brain cells that act as the brain's supervisors. These cells manage a crucial molecule called GABA through a specialised transporter (GAT-3), which acts like a traffic controller for brain signals.
When this system doesn't work properly, it can lead to various conditions that affect millions worldwide, including epilepsy, schizophrenia, and autism spectrum disorder (ASD).

What We'll Do
Using advanced computer modelling, this project will create detailed models of how brain cells interact, study how GABA levels affect brain circuit behaviour and investigate how changes in this system might lead to neurological conditions.
Innovation and Impact
This research combines cutting-edge computational neuroscience with real-world medical applications. By understanding how these cellular "traffic controllers" work, we could develop more effective treatments for neurological disorders and advance our understanding of how the healthy brain works.

Throughout this PhD, you'll gain expertise in:
* Computational neuroscience modelling
* Biophysical modelling of cellular processes
* Scientific programming and version control
* Collaboration with experimental neuroscientists

Ideal Candidate Profile
The ideal candidate will hold a strong undergraduate or master's degree in computational neuroscience, computer science, mathematics, biology, or related fields. While computational modelling experience is beneficial, we value analytical ability and enthusiasm above all. The ideal candidate will be driven by a desire to advance neurological disorder research, combining problem-solving skills with genuine interest in applying computational methods to biological questions.

Essential criteria

Applicants should hold, or expect to obtain, a First or Upper Second Class Honours Degree in a subject relevant to the proposed area of study.

We may also consider applications from those who hold equivalent qualifications, for example, a Lower Second Class Honours Degree plus a Master’s Degree with Distinction.

In exceptional circumstances, the University may consider a portfolio of evidence from applicants who have appropriate professional experience which is equivalent to the learning outcomes of an Honours degree in lieu of academic qualifications.

• Experience using research methods or other approaches relevant to the subject domain
• A demonstrable interest in the research area associated with the studentship

Desirable Criteria

If the University receives a large number of applicants for the project, the following desirable criteria may be applied to shortlist applicants for interview.

• First Class Honours (1st) Degree
• Masters at 70%
• For VCRS Awards, Masters at 75%
• Experience using research methods or other approaches relevant to the subject domain
• Work experience relevant to the proposed project
• Publications - peer-reviewed
• Experience of presentation of research findings

Equal Opportunities

The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities.

Appointment will be made on merit.

Funding and eligibility

This project is funded by:

• Department for the Economy (DfE)
• Vice Chancellor's Research Scholarship (VCRS)

Our fully funded PhD scholarships will cover tuition fees and provide a maintenance allowance of £19,237 (tbc) per annum for three years* (subject to satisfactory academic performance).  A Research Training Support Grant (RTSG) of £900 per annum is also available.

These scholarships, funded via the Department for the Economy (DfE) and the Vice Chancellor’s Research Scholarships (VCRS), are open to applicants worldwide, regardless of residency or domicile.

Applicants who already hold a doctoral degree or who have been registered on a programme of research leading to the award of a doctoral degree on a full-time basis for more than one year (or part-time equivalent) are NOT eligible to apply for an award.

*Part time PhD scholarships may be available, based on 0.5 of the full time rate, and will require a six year registration period (individual project advertisements will note where part time options apply).

Due consideration should be given to financing your studies.